Figure 6 | Scientific Reports

Figure 6

From: Disulfiram and BKM120 in Combination with Chemotherapy Impede Tumor Progression and Delay Tumor Recurrence in Tumor Initiating Cell-Rich TNBC

Figure 6

Combinational effect of DSF/Cu and BKM120 on TIC population and bulk cancer cells. (A,C) Representative figures show dose dependent decrease of ALDH+ (A) and CD44+/CD24− (C) population due to the co-treatment of DSF/Cu and BKM120. L: Low dose (DSF/Cu 0.1 µM and BKM120 1 µM). H: High dose (DSF/Cu 0.5 µM and BKM120 5 µM). (B,D) Summary of the co-treatment effect of DSF/Cu and BKM120 mixture on TIC populations. L: Low dose (DSF/Cu 0.1 µM and BKM120 1 µM). H: High dose (DSF/Cu 0.5 µM and BKM120 5 µM). For panel B-D, one-way ANOVA followed by multiple comparisons was used with P < 0.05 as statistically significant. (E,F) Low dose of DSF/Cu and BKM120 mixture (0.075 µM and 1.125 µM, respectively) sensitizes MDA-MB468 cells to chemotherapeutic agent Dox (E) and PAC (F) DSF/Cu and BKM120 mixture along with indicated chemotherapeutic agents were added to MDA-MB468 cells for 24 hours and then were replaced with normal medium for another 24 hours before measured by MTT. For panel E-F, two-way ANOVA with multiple comparison was used with P < 0.05 as statistically significant.

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