Figure 7 | Scientific Reports

Figure 7

From: Disulfiram and BKM120 in Combination with Chemotherapy Impede Tumor Progression and Delay Tumor Recurrence in Tumor Initiating Cell-Rich TNBC

Figure 7

The effect of combination therapy. (A) The therapeutic schedule to examine the effect of DSF-BKM120 mixture in combination with chemotherapy for TNBC treatment. There are six different treatment groups: (a) Vehicle; (b) Taxol; (c) 50 mg/kg DSF and 50 mg/kg BKM; (d) 40 mg/kg DSF plus 32 mg/kg BKM; (e) 7.5 mg/kg Taxol plus 50 mg/kg DSF and 50 mg/kg BKM; and (f) 7.5 mg/kg Taxol plus 40 mg/kg DSF and 32 mg/kg BKM. (B) The effect of 6 different treatments on overall tumor burden (mg) before first mouse in treatment group reached ending point. (C) The effect of 6 different treatments on tumor burden latency (days to reach end points). (D) The effect of treatments including Taxol alone (b group), high (e group) and low (f group) dose of DSF-BKM120 mixture in combination with Taxol on tumor recurrence. (E) The Kaplan-Meier survival plot showed the time of mice in 6 treatment groups reached ending points. Only the high dose DSF-BKM120 mixture in combination with chemotherapy demonstrated statistical significance in comparison with Taxol treatment alone (P < 0.001).

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