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Figure 1

From: Cyclic undecapeptide Cyclosporin A mediated inhibition of amyloid synthesis: Implications in alleviation of amyloid induced neurotoxicity

Figure 1

Effect of cyclic peptide CsA on kinetics of OVA amyloidogenesis. (A) The effect of CsA on synthesis of OVA amyloid was monitored by determining ThT fluorescence associated with as-formed OVA amyloid. The OVA amyloid synthesis followed a sigmoidal kinetics that involves around 5 h lag time before attainment of exponential phase. The cyclic peptide CsA inhibits OVA-amyloid synthesis in concentration dependent manner. (B) Absorption fluorescence spectra of ThT bound mature OVA amyloid species generated at 120 h time point. The effect of presence of CsA on generation of OVA amyloid was monitored by plotting fluorescence absorption spectrum of mature OVA amyloid formed at 120 h time point. The CsA inhibited OVA amyloid synthesis in dose dependent manner. The native ova failed to bind with ThT dye.

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