Figure 4

Gene network analysis showing association between significantly modulated genes. Genes showing no association are placed separately from the gene network Different coloured edges with arrows shows the direction of interactions. Circles with + and − symbols represents positive and negative regulations. Symbols (small squares, triangles and circles) shows various modes of regulations like, binding, expression, transport, metabolism etc. Various other entities not reported in our study (small molecules, genes, function, enzymes etc) to which these genes interact are enclosed in different colored shapes. Details of the graphical display of these associations are provided in Supplementary Fig. S3.