Table 1 Enrichment of GO terms using DAVID functional annotation tool of epigenetically modulated gene expression in FCD type II.

From: Genome-wide DNA Methylation and RNAseq Analyses Identify Aberrant Signalling Pathways in Focal Cortical Dysplasia (FCD) Type II

Term

Count

p-value

Term

Count

p-value

Cluster 1 Enrichment score- 2.54

Cluster 5 Enrichment score- 1.55

GO:0050767- regulation of neurogenesis

8

1.5E-3

GO:0046872- metal ion binding

54

2.3E-2

GO:0051960- regulation of nervous system

8

3.4E-3

GO:0043169- cation binding

54

2.8E-2

GO:0060284- regulation of cell development

8

4.9E-3

GO:0043167- ion binding

54

3.6E-2

Cluster 2 Enrichment score- 2.33

Cluster 6 Enrichment score- 1.46

GO:0045892-neagtive regulation of transcription

13

2.4E-3

GO:0042981- regulation of apoptotic process

15

3.3E-2

GO:0010629- negative regulation of gene expression

13

5.1E-3

GO:0043067- regulation of programmed cell death

15

3.6E-2

GO:0045934- negative regulation of nucleobase-containing compound metabolic process

13

5.8E-3

GO:0010941- regulation of cell death

15

3.7E-2

GO:0051172- negative regulation of nitrogen compound metabolic process

13

6.4E-3

   

Cluster 3 Enrichment score- 1.98

Cluster 7 Enrichment score- 1.37

GO:0016477- cell migration

9

7.0E-3

GO:0005524- Protein kinase, ATP binding site

10

3.2E-2

GO:0051674- localization of cell

9

1.3E-2

GO:0004672- Protein kinase core

10

4.0E-2

GO:0048870- cell motility

9

1.3E-2

   

Cluster 4 Enrichment score- 1.98

Cluster 8 Enrichment score- 1.09

GO:0043066- negative regulation of apoptotic process

10

9.9E-3

GO:0005261- cation channel activity

8

2.1E-2

GO:0005216- ion channel activity

8

9.6E-2

GO:0022838- substrate-specific channel activity

8

1.1E-1

GO:0043069- negative regulation of programmed cell death

10

1.1E-2

GO:0015267- channel activity

8

1.2E-1

negative regulation of cell death

10

1.1E-2

GO:0022803- passive transmembrane transporter activity

8

1.2E-1

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