Table 1 Associations between New Metrics and CT disease and Respiratory Morbidity.

From: New Spirometry Indices for Detecting Mild Airflow Obstruction

 

Parameter D

Transition Point

Transition Distance

Univariate regression coefficient

Multivariable regression coefficient*

Univariate regression coefficient

Multivariable regression coefficient*

Univariate regression coefficient

Multivariable regression coefficient*

% Emphysema

88.7 (84.9 to 92.6)

82.1 (78.0 to 86.2)

−0.34 (−0.36 to −0.33)

−0.33 (−0.34 to −0.31)

−0.016 (−0.017 to −0.015)

−0.014 (−0.015 to −0.013)

%PRMfSAD

176.7 (169.6 to 183.8)

153.5 (146.2 to 160.8)

−0.53 (−0.55 to −0.51)

−0.49 (−0.51 to −0.46)

−0.023 (−0.025 to −0.022)

−0.020 (−0.021 to −0.019)

WallArea%

21.2 (19.4 to 23.1)

30.1 (28.3 to 31.9)

−0.094 (−0.099 to −0.090)

−0.114 (−0.119 to −0.110)

−0.004 (−0.005 to −0.004)

−0.005 (−0.005 to −0.004)

SGRQ

157.5 (145.6 to 169.5)

206.5 (194.1 to 218.8)

−0.70 (−0.73 to −0.67)

−0.80 (−0.84 to −0.77)

−0.034 (−0.036 to −0.032)

−0.035 (−0.037 to −0.033)

mMRC

8.1 (7.4 to 8.9)

11.2 (10.4 to 12.0)

−0.042 (−0.044 to −0.040)

−0.045 (−0.047 to −0.043)

−0.002 (−0.002 to −0.002)

−0.002 (−0.002 to −0.002)

  1. *Adjusted for age, sex, race, and BMI as well as scanner type in the case of CT parameters.
  2. All p values were < 0.001.
  3. PRM = Parametric response mapping. fSAD = Functional small airway disease. SQRQ = St. George’s Respiratory Questionnaire. MMRC = Modified Medical Research Council Dyspnea Scale.