Figure 5

Transcription factor binding motif analyses of mesenchymal stem cells (MSCs) of different tissue origins. (a) Motifs with differential accessibility among the MSCs were identified using ChromVar. Identified motifs were sorted using the variability score. (b) Motif accessibility in each cell type is visualized using the deviation score. (c) Gene expression levels of the transcription factors identified in (b). The expression levels were shown as TPM (transcripts per million). (d) Association between chromatin accessibility and gene expression. Chromatin accessibility at the promoter regions of the differentially expressed genes (DEGs) identified in Fig. 2d is shown. Promoter region is defined as +/− 1 kb from transcriptional start site (TSS). ATAC-seq read counts in the promoter regions of DEGs were calculated and shown in a heatmap.