Figure 1

Transcriptome landscapes of different mouse chromosomes in differentiating neural stem cells with or without ethanol treatments. The Circos displays from the outmost ring to the inner rings: chromosome number of mm10 reference genome, cytobands, and heatmaps are shown with three replicates for each condition, and the histogram (shown as the inner most ring). The heatmaps are displayed as RNA-seq reads number per 1 Mb span with high (red) and low (blue). The histogram displays the differential expression between two conditions with up-regulated (red) or down-regulated (blue). (A) The transcriptomes of controls. The heatmap displays D0, D2, and D8, each having three replicates, from outer rings to the inner rings. The inner most histogram shows differential gene expression of D8 versus D2. (B) The transcriptome of D2. The heatmap displays D2 control (outer) and D2 ethanol binge (inner). The histogram shows the differential gene expression program of D2 control versus D2 ethanol. (C) The transcriptome of D8 is shown. The heatmap displays D8 control (outer ring) and D8 continuous ethanol (inner ring). The histogram shows the differential gene expression program of D8 control versus day 8 ethanol. (D) The transcriptome of D8. The heatmap displayed D8 control (outer ring) and D8 ethanol withdrawal (inner ring). The histogram shows the differential gene expression program of D8 control versus D8 ethanol withdrawal. The highlighted genes are the 2-fold changes or top 10 genes.