Figure 3 | Scientific Reports

Figure 3

From: Plasmodium falciparum infected erythrocytes can bind to host receptors integrins αVβ3 and αVβ6 through DBLδ1_D4 domain of PFL2665c PfEMP1 protein

Figure 3

Binding of bead-immobilized single DBL domains containing RGD motif to αVβ3 (A) and αVβ6 (B) integrins at two concentrations. Gray bars, 1 μg/ml; black bars, 5 μg/ml. AFU, Arbitrary fluorescence units. Control value for HisAdEx construct was subtracted from binding of domain constructs. Bars represent means of duplicate measurements. Error bars indicate Standard Deviations (SD). Differences in binding between each domain and control construct for each concentration were calculated by one-way ANOVA using Holm-Sidak’s multiple comparison tests. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. These experiments were repeated at least twice with similar qualitative results.

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