Figure 1 | Scientific Reports

Figure 1

From: Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from Porcine Respiratory and Reproductive virus infections

Figure 1

Scheme of safety and immunogenicity targeted-pig trial. Timeline of immunizations was the same for both strategies. (a) For safety trial, animals receive two doses of EVs injected intramuscularly (Day 0 and 21) and euthanised at day 51. (b) For immunogenicity trial, animals received either two doses of EV-enriched fractions or synthetic viral peptides (day 0 and 21) and all then boosted with synthetic viral peptides (day 42). All animals were euthanised at day 63. Serum samples were collected in all timepoints.

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