Table 7 Summary of principal component regression on nicotine self-administration.

From: Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats

Phenotype

Sex

Significant PCs

R-squared

F

p

Nicotine infusion first 3 FR sessions

F

6, 7, 12, 17, 18, 22

0.16

4.55

4.0 × 10−7

Nicotine infusion first 3 FR sessions

M

5, 18, 19, 21, 23, 25

0.14

3.31

3.9 × 10−5

Nicotine infusion last 3 FR sessions

F

12, 19, 31

0.09

3.48

4.0 × 10−4

Nicotine infusion last 3 FR sessions

M

1, 2, 3, 5, 6, 13, 15, 17, 20, 30

0.19

4.10

2.2 × 10−7

Nicotine infusion PR session

F

4, 5, 6, 18, 22

0.16

2.66

2.0 × 10−4

Nicotine infusion PR session

M

1, 5, 20, 21, 22, 31

0.19

3.43

3.6 × 10−6

Reinstatement, active lick

F

6, 19

0.10

2.84

2.0 × 10−3

Reinstatement, active lick

M

5, 14, 17, 20, 21, 23

0.17

3.06

2.9 × 10−5

  1. The social behavior and anxiety associated PCs that frequently significant for nicotine traits were highlighted in bold or underlined, respectively.
Back to article page