Figure 2
From: Intratumoral heterogeneity of endogenous tumor cell invasive behavior in human glioblastoma
Surface topography analysis highlights a subpopulation of glioblastoma cells with increased bursting activity. (A,C). Line based schematics of differences in Euclidean distance traversed per unit time during a burst of cell migration (red line). (B) Surface topography map demonstrates bursting behavior of cells from a representative tumor cell population (GBM-8 shown, analysis performed in all tumors n = 7). Peak height represents speed (μm/hr) with a color-coded heat map (right). (D). Cells with frequent bursting behavior (increased standard deviation of instantaneous speed) represent a small subpopulation within the tumor. (E) There is a positive correlation between standard deviation of instantaneous speed and mean effective speed for individual cells (Spearman correlation coefficient, r = 0.93, p < 0.0001).
