Table 2 A, 7-L lab-scale fermentation; B, 50-L pilot-scale fermentation; Pf, maximum MA production; Xf, maximum dry cell weight; Sf, final residual glucose concentration; Qp, average volumetric MA production rate; qp, average specific MA production rate; Yp/x, specific MA production; Yp/s, MA production yield based on glucose; Yx/s, DCW yield based on glucose. The data represent the mean (±standard deviation) of two independent experiments.
From: Corynebacterium Cell Factory Design and Culture Process Optimization for Muconic Acid Biosynthesis
A (7-L) | B (50-L) | |
|---|---|---|
Pf (g IA/L) | 37.7 ± 2.7 | 53.8 ± 5.5 |
Xf (g DCW/L) | 45.3 ± 2.7 | 51.8 ± 7.2 |
Sf (g glucose/ L) | 0 | 0 |
Qp (g MA/L/hr) | 0.216 ± 0.027 | 0.34 ± 0.053 |
qp (g MA/g DCW/hr) | 0.005 ± 0.001 | 0.006 ± 0.002 |
Yp/x (g MA/g DCW) | 0.892 ± 0.072 | 1.074 ± 0.256 |
Yp/s (g MA/g glucose) | 0.165 ± 0.013 | 0.197 ± 0.011 |
Yx/s (g DCW/g glucose) | 0.185 ± 0.001 | 0.192 ± 0.036 |
