Figure 1
From: Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
Deletion of presenilin 2 does not affect hippocampal adult neurogenesis. (a) Representative images of Ki67+ dividing NPCs in wild-type (WT) and germline presenilin 2 knockout mice (PS2−/−) (b) Quantification of Ki67+ cells shows no difference between the genotypic groups. (c) Representative images of DCX+ immature neurons in WT and PS2−/− mice. (d) Quantification of DCX+ cells shows no difference between WT and PS2−/− mice (n = 8 mice/genotype). (e) Schematic of retroviral injection into the dentate gyrus (DG) of WT and PS2−/− mice. (f ) Representative images of RFP+ cells expressing NeuN+ at 30 dpi. Scale bar, 20 μm. (g) Quantification of the number of RFP+ cells shows no difference between genotype. (h) Quantification of the proportion of RFP+ cells that express NeuN shows no difference between genotype (n = 4 mice/genotype). Scale bar, 60 μm (a,c), 20 μm (f). Data are presented as the mean ± SEM.
