Figure 4
From: Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
Intact electrophysiological properties of PS-null NPCs. (a) Representative two-photon image of a GFPCre+ cell filled with Alexa 594 dye. Scale bar, 10 μm. (b) Membrane Resistance (RM), resting membrane potential (VRest), and estimated cell capacitance (CM) were similar between the two genotypes (n = 3 mice/genotype). (c) Representative voltage traces of action potential trains in response to direct current injection. Scale bar, 10 mV; 100 ms. (d) Action potential amplitude and the time to peak were comparable between the two genotypes (n = 3 mice/genotype). (e) Representative current traces of glutamate receptor mediated currents held at −70 and +40 mV. Scale bar, 40 pA, 50 ms (top); 20 pA, 50 ms (bottom). (f) AMPAR:NMDAR ratios were similar between control and vDKO in seven-eight week old virus labeled cells (n = 3–4 mice/genotype). Data are presented as the mean ± SEM.
