Figure 5
From: Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
Running-induced neurogenesis occurs in the absence of presenilins. (a) Timeline of experiment. (b) Representative images of virally labeled cells in the dentate gyrus of mice with locked, non-functional wheel (lock) and functional running wheels (run). Scale bar, 50 μm (upper), 20 μm (lower). (c) Quantification of number of GFPCre+ RFP+ virally labeled cells significantly increased with running in both control and vDKO groups (F(1,28) = 20.7, p < 0.0001). (d) Quantification of survival shows no change in survival ratio following running in control and vDKO mice. (n = 9 mice/genotype for lock wheels; 7 mice/genotype for running wheels). Data are presented as the mean ± SEM.
