Figure 7
From: Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
Ablating presenilins from nestin-expressing and progeny does not affect neurogenesis. (a) Representative images of YFP+ cells expressing the NSC markers nestin and GFAP (arrowheads) at 12 days post tamoxifen (TAM). (b) Quantification of proportion of YFP+ Nestin+ GFAP+ cells among all YFP+ population shows no change between genotypes (n = 4 mice/genotype). (c) Representative images of YFP+ cells expressing cell division marker Ki67 (arrowheads) at 12 days post TAM. (d) Quantification of proportion of YFP+ Ki67+ cells among all YFP+ population shows no change between genotypes (n = 6 mice/genotype). (e) Representative images of YFP+ cells expressing immature neuron marker DCX at 12 days post TAM. (f) Quantification of proportion of YFP+ DCX+ cells among all YFP+ population shows no change between genotypes (n = 6 mice/genotype). (g) Representative images of YFP+ cells expressing post-mitotic neuronal marker NeuN at 30 days post TAM. (h) Quantification of proportion of YFP+ NeuN+ cells among all YFP+ population shows no change between genotypes (n = 3 mice/genotype. Scale bars (a,c,e,g), 20 μm. Data are presented as the mean ± SEM.
