Figure 5 | Scientific Reports

Figure 5

From: Sodium current inhibition following stimulation of exchange protein directly activated by cyclic-3′,5′-adenosine monophosphate (Epac) in murine skeletal muscle

Figure 5

Inclusion of dantrolene abolishes the inhibitory effect of 8-CPT on inward currents. (a,b) Membrane ion currents (a) before and (b) following challenge by a combination of 8-CPT and dantrolene in response to pulse protocol consisting of V1 and V2 steps showing increased I1 and decreased I2 with increasingly depolarising V1 steps that were not affected by the pharmacological challenge. (c–f) Plots of peak inward currents, I1 and I2, in response to (c,d) V1 steps and (e,f) V2 steps respectively. These reflect the voltage dependences of inward current (c,d) activation and (e,f) inactivation (c,e) before and (d,f) following pharmacological challenge. Data from (a,c,e) patch 2102st03.dat (sweeps 1–66), (b,d,f) patch 2102st05 (sweeps 1–66); V0 = −40, V1 = from −40 to +120, V2 = +100 mV relative to the resting potential for both data sets.

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