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Figure 1

From: In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning

Figure 1

Pups exposed to in utero and lactational fluoxetine have compromised trabecular femoral bone. Dams were injected intraperitoneally with either saline or 20 mg/kg fluoxetine from day 0 of pregnancy through day 21 of lactation. At weaning, femurs were extracted from n = 4 and n = 8 female pups of saline dams and n = 6 male and n = 8 female pups of fluoxetine dams and subjected to microCT analysis. (A) Bone volume/tissue volume. (B) 3D reconstruction images of distal femur trabecular bone. The scale bar represents 100 microns. (C) Trabecular number (mm−1). (D) Trabecular thickness (μm). (E) Trabecular spacing (μm). (F) Trabecular bone mineral density (mgHg/cm3). Data were analyzed with a Student’s t-test and are presented as mean ± SEM.

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