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Figure 2

From: In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning

Figure 2

Pups exposed to in utero and lactational fluoxetine have compromised cortical femoral bone and shorter femurs. Dams were injected intraperitoneally with either saline or 20 mg/kg fluoxetine from day 0 of pregnancy through day 21 of lactation. At weaning, femurs were extracted from n = 4 and n = 8 female pups of saline dams and n = 6 male and n = 8 female pups of fluoxetine dams and subjected to microCT analysis. (A) Cortical thickness (mm). (B) Cortical porosity (%). (C) Cortical bone mineral density (mgHg/cm3). (D) Femur length (mm). (E,F) Isolated femurs from saline-treated (left) and fluoxetine-treated (right) mice are shown. Scale bar in mm. Males are shown in (E) and females are shown in (F). Data were analyzed with a Student’s t-test and are presented as mean ± SEM.

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