Figure 5
Vincristine induces correlated times-to-death in sister cells. (a) Dose response curve, i.e. percentage of dead cells versus drug concentration for unsynchronized and synchronized cells. Error bars were calculated to reflect the 95% interval. (b) Distributions of time-to-death of the normalized number of cells across all drug concentrations for both the unsynchronized and synchronized populations. Note that synchronization does not affect the time-to-death distribution. (c) Sister cell pairs derived from the unsynchronized population (n = 93 pairs of sister cells) exhibit similar times-to-death (r = 0.54, p-value: 1.15 × 10−7), while for unrelated cells in the synchronized population (n = 129 pairs) no correlation is observed (r = 0.05, p-value: 0.05). The ellipses indicate the directionality of the correlation.
