Figure 1 | Scientific Reports

Figure 1

From: Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb

Figure 1

No significant locomotor impairments in mice with partial depletion of SN dopaminergic neurons after injection of 6-OHDA. (a,c) TH immunostaining in SN (a) and OB (c) from a representative mouse. Left and right images are contralateral and ipsilateral to the 6-OHDA SN injection site, respectively. (b,d) Comparison of the number of TH+ cells in the ipsilateral and contralateral SN (b) and OB (d) after unilateral SN 6-OHDA across all the 6 mice. (e,f) Time on the rod in the rotarod test for 6-OHDA treated mice and sham mice injected unilaterally (e) or bilaterally (f). (g) Number of apomorphine-induced rotations in 30 minutes in 6-OHDA treated mice and sham mice. (h) Time on the rod in the rotarod test in 6-OHDA treated mice and sham mice 28 days after drug injection. Error bars represent s.e. **P < 0.01; ***P < 0.001; N.S., not significant.

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