Figure 2 | Scientific Reports

Figure 2

From: Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb

Figure 2

Injection of 6-OHDA into the SN impairs odor discrimination and odor spatial memory in mice. (a1) Schematic for the odor habituation/dishabituation test in C57BL/6 J mice. (a2,a3) Odor habituation (the same odor stimulation repeated four times with 2 min interval, 1st–4th trial) and dishabituation (novel odorant on the 5th trial) in sham mice (a2, n = 14) and 6-OHDA treated mice (a3, n = 14). (b1) Schematic for the olfactory spatial memory test in C57BL/6 J mice. (b2,b3) Number of visits to the control and switched odors in the training trials (trial 1 and 2) and the recall trial (trial 3) in sham mice (b2, n = 10) and 6-OHDA treated mice (b3, n = 10). (c) Latency to locate a food pellet in sham and 6-OHDA treated mice for a buried food pellet (Buried) or food on the surface of the bedding (Visual). *P < 0.05; ***P < 0.001; N.S., not significant.

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