Table 1 Dimensions of non-infectious recombinant PrP fibrils and infectious RML prion rods by EM and AFM.
Sample | Method | Width mean ± SD (nm) | Length mean ± SD (nm) | Height mean ± SD (nm) |
---|---|---|---|---|
Recombinant PrP fibrils | Negative stain EM (n = 18 fibrils) | 10.4 ± 1.2 | >700 | — |
Cryo-EM (n = 18 fibrils) | 9.3 ± 0.8 | >700 | — | |
AFM (n = 6 fibrils) | 11.3 ± 2.2 | >700 | 4.0 ± 0.8 | |
Ex vivo RML prion rods | Negative stain EM (n = 18 rods) | 20.2 ± 1.9* | 127.5 ± 41.3 | |
Cryo EM (n = 18 rods) | 19.4 ± 2.3§ | 118.3 ± 23.8 | ||
AFM (n = 8 rods) | 26.5 ± 0.3# | 111.5 ± 17.4 | 9.2 ± 0.5$ |