Figure 1 | Scientific Reports

Figure 1

From: An integrative modeling approach to the age-performance relationship in mammals at the cellular scale

Figure 1

IMAP1 with three sets of parameters values. (a) Green line corresponds to \({\alpha }_{0}^{\ast }=1000\), \({\alpha }_{r}^{\ast }=100\), \({\beta }_{r}^{\ast }=5\), the blue one is \({\alpha }_{0}^{\ast }=50\), \({\alpha }_{r}^{\ast }=15\), \({\beta }_{r}^{\ast }=10\) and the red one is \({\alpha }_{0}^{\ast }=200\), \({\alpha }_{r}^{\ast }=10\), \({\beta }_{r}^{\ast }=20\). The (b) panel shows the overall cell population size, reflecting the average proliferation capacity while panel (c) shows the values embedding adverse effects of senescence, resulting in functionality drop.

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