Figure 10
From: ENOblock inhibits the pathology of diet-induced obesity
Effect of ENOblock or metformin treatment on HOM-IR and WAT inflammatory status in diet-induced obese mice. (A,B) Insulin serum level and insulin resistance in ENOblock or metformin treated HFD mice over 8 weeks of treatment. n = 6–10. (C) Representative photographs of dissected gonadal WAT. (D) Gonadal WAT weight in the treated mice. n = 6–10. (E) Representative flow cytometry plots of WAT-derived inflammatory cells stained with antibodies for the pan-macrophage marker, CD68 (macrosialin) and the M2 anti-inflammatory macrophage marker, CD206 (mannose receptor. (F) Quantification of the percentage of M2 type macrophages in the inflammatory population of WAT from the treated mice. n = 6. ns: not significantly different. *, ** or ***: significantly different from the corresponding ‘SFD-Normal’ or ‘SFD-Control’ (Standard Fat Diet-none-treated normal healthy mouse group) respectively with p < 0.05, p < 0.01 or p < 0.001; ## or ###: significantly different from the corresponding ‘HFD-none’ or ‘HFD-Control’ (HFD-none-treated control mouse group) sample with p < 0.01 or p < 0.001; ж, жж or жжж: significantly different from the corresponding ‘HFD-Metf’ sample respectively with p < 0.05, p < 0.01 or p < 0.001.
