Figure 11
From: ENOblock inhibits the pathology of diet-induced obesity
Schematic of the consequences of ENOblock treatment on the progression of diet-induced obesity. In HFD mice, ENOblock treatment induces the nuclear localization of enolase and its secondary moonlighting activity as a transcriptional repressor. Key regulators of adiposity, gluconeogenesis and inflammatory response are downregulated, with a concomitant increase in adipose tissue mitochondrial membrane depolarization via Ucp-3 upregulation. This combined pattern of gene expression modulation inhibits the progression of obesity and related complications. The copyright holder (Mrs Hyunju Park) has granted permission to Springer Nature Limited to publish the images of the mice in Fig. 11 of the manuscript entitled “ENOblock inhibits the pathology of diet-induced obesity” by Cho, et al., under a CC BY open access license.
