Figure 3 | Scientific Reports

Figure 3

From: Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Figure 3

Urothelial thickness is significantly decreased following Foxa1 knockout in Upk2-HRAS* mice. Urothelial thickness is significantly increased in Upk2-HRAS* mice relative to control (P = 0.006; Kruskal-Wallis H test), confirming the presence of urothelial hyperplasia. While KO of one copy of Foxa1 in Upk2-HRAS* mice has minimal impact compared to control (P = 0.03; Kruskal-Wallis H test), urothelial thickness following homozygous Foxa1 KO in Upk2-HRAS* mice was not significantly thicker than control urothelium.

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