Figure 2 | Scientific Reports

Figure 2

From: Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method 

Figure 2

(A) Schematic depicting the process of generating BCBM PDXs in this study. (B) Left panel: Kaplan–Meier survival curves of DF-BM#Ni7 and DF-BM#656-bearing mice by intracarotid artery injection (ica, red) compared to intracranial injection (ic, black). **P < 0.01. Right panel: Bioluminescence imaging analysis of mice bearing DF-BM#Ni7 and DF-BM#656 tumors at indicated time after injecting. (C) The treatment histories of BCBM patients who contributed their specimen to the derivation of PDXs.

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