Figure 3

(A) Histologic and immunophenotypic analysis of HER2, ER, and Ki67 on the orthotopic brain metastatic PDXs (top panel: DF-BM#Ni7; bottom panel: DF-BM#656) by intracranial injection (ic PDX) or by intracarotid artery injection (ica PDX), and their matched patient specimens (Scale bars = 50 μm). (B) Patterns of genome-wide DNA copy number variations in orthotopic brain metastatic PDXs (top panel: DF-BM#Ni7; bottom panel: DF-BM#656) by intracranial injection (ic PDX) or by intracarotid artery injection (ica PDX), and their matched patient specimens.