Figure 8 | Scientific Reports

Figure 8

From: DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

Figure 8

Neuronal activity-induced IEG and basal transcriptional expression. WT1, A-T1 and ATM-KO neurons at DIV55 were incubated overnight with TTX and then untreated or treated with KCl for 1 hr, harvested and analysed by RNA-seq. (a) Heat map of the stimulus-induced IEGs. (b) heat map of genes differentially expressed in unperturbed WT1 compared to A-T1 and ATM-KO1 neurons. These genes are involved in CNS development, maintenance, and synaptic plasticity. Data are of two independent replicates.

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