Table 2 Effect of pyridine derivatives on the H2S-synthesizing activity of tCBS, CSE and MST.
tCBS | CSE | MST | |||||||
|---|---|---|---|---|---|---|---|---|---|
H2S production (%) (Z’ factor: 0.60) | CV | Z-score | H2S production (%) (Z’ factor: 0.78) | CV | Z-score | H2S production (%) (Z’ factor: 0.51) | CV | Z-score | |
Control | 100.0 (N = 18) | 11.6 | — | 100.0 (N = 9) | 12.0 | — | 100.0 (N = 9) | 6.8 | |
Blank | 5.4 (N = 18) | 37.2 | 8.2 | 5.2 (N = 9) | 27.5 | 7.9 | 16.9 (N = 9) | 48.5 | 12.1 |
AOAA | 8.8 | 12.1 | 7.9 | 6.7 | 59.7 | 7.8 | — | — | — |
C1* | 98.4 | 3.4 | 0.1 | 102.3 | 2.8 | −0.2 | 103.0 | 7.8 | −0.4 |
C2 | 92.4 | 4.2 | 0.7 | 98.4 | 2.7 | 0.1 | 102.5 | 0.5 | −0.4 |
C3 | 89.5 | 5.7 | 0.9 | 96.7 | 2.5 | 0.3 | 103.9 | 5.3 | −0.6 |
C4 | 77.4 | 8.2 | 2.0 | 101.0 | 3.0 | −0.1 | 100.0 | 4.1 | 0.0 |
C5 | 93.5 | 7.9 | 0.6 | 122.0 | 0.0 | −1.8 | 107.5 | 0.6 | −1.1 |
C6* | 79.8 | 6.6 | 1.7 | 92.6 | 0.9 | 0.6 | 99.7 | 4.0 | 0.0 |
C7 | 95.1 | 2.1 | 0.4 | 97.3 | 1.8 | 0.2 | 99.9 | 6.8 | 0.0 |
C8 | 92.4 | 9.8 | 0.7 | 94.0 | 1.4 | 0.5 | 87.4 | 7.5 | 1.8 |
C9 | 97.1 | 1.7 | 0.2 | 90.3 | 3.6 | 0.8 | 96.5 | 3.4 | 0.5 |
C10 | 103.8 | 11.9 | −0.3 | 98.0 | 1.0 | 0.2 | 98.0 | 3.7 | 0.3 |
C11 | 108.6 | 7.3 | −0.7 | 106.9 | 8.4 | −0.6 | 89.6 | 0.5 | 1.5 |
C12* | 97.0 | 16.7 | 0.3 | 90.8 | 5.4 | 0.8 | 103.6 | 4.0 | −0.5 |
C13 | 97.9 | 8.7 | 0.2 | 89.8 | 2.4 | 0.9 | 93.1 | 3.7 | 1.0 |
C14 | 85.0 | 2.8 | 1.3 | 93.0 | 6.5 | 0.6 | 106.3 | 7.4 | −0.9 |
C15 | 80.7 | 1.1 | 1.7 | 92.6 | 2.4 | 0.6 | 91.2 | 2.1 | 1.3 |
C16 | 122.5 | 1.7 | −2.0 | 93.8 | 15.3 | 0.5 | 104.8 | 7.9 | −0.7 |
C17 | 109.2 | 3.9 | −0.8 | 97.2 | 7.6 | 0.2 | 102.3 | 3.9 | −0.3 |
C18 | 105.2 | 13.2 | −0.5 | 94.4 | 2.3 | 0.5 | 101.9 | 2.1 | −0.3 |
C19 | 118.4 | 3.2 | −1.6 | 96.6 | 4.4 | 0.3 | 103.9 | 6.6 | −0.6 |
C20* | 101.5 | 1.3 | −0.1 | 116.2 | 18.8 | −1.4 | 103.4 | 9.0 | −0.5 |
C21* | 79.0 | 7.6 | 1.8 | 101.0 | 1.0 | −0.1 | 103.3 | 3.1 | −0.5 |
C22 | 68.3 | 4.2 | 2.7 | 100.6 | 8.2 | −0.1 | 107.7 | 1.8 | −1.1 |
C23 | 115.8 | 8.7 | −1.4 | 91.3 | 3.3 | 0.7 | 103.4 | 2.0 | −0.5 |
C24* | 94.7 | 5.5 | 0.5 | 112.2 | 1.6 | −1.0 | 101.6 | 3.6 | −0.2 |
C25 | 94.7 | 14.1 | 0.5 | 102.9 | 21.7 | −0.2 | 106.6 | 3.5 | −1.0 |
C26 | 97.5 | 23.2 | 0.2 | 99.8 | 1.5 | 0.0 | 97.2 | 4.0 | 0.4 |
C27 | 104.8 | 4.9 | −0.4 | 96.2 | 3.6 | 0.3 | 98.8 | 1.3 | 0.2 |
C28 | 93.8 | 16.7 | 0.5 | 91.8 | 14.0 | 0.7 | 108.0 | 2.7 | −1.2 |
C29 | 81.3 | 22.5 | 1.6 | 97.4 | 5.3 | 0.2 | 107.6 | 6.4 | −1.1 |
C30 | 50.3 | 12.9 | 4.3 | 64.2 | 9.7 | 3.0 | 130.3 | 2.3 | −4.4 |
C31* | 60.7 | 24.6 | 3.4 | 38.4 | 5.1 | 5.1 | 119.1 | 6.8 | −2.8 |
