Figure 1
From: Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis
Basic structure of class II HLA. (A) HLA-DR is constructed of α- (gray) and β- (blue) chains to restrict antigenic peptide (magenta ribbon). (B) Polymorphic residues of HLA-DR β-chain are marked as spheres on the top view of binding cleft. (C) Sequence alignment of HLA-DR β-chain, whereas the residues of HLA-DR α-chain are conserved (data not shown).
