Figure 4
From: Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis
Top1 peptide binding with various HLA-DR molecules. (A) A superimposition of representative Top1 in five MD systems showing a side view of HLA-DR binding cleft. The Top1 binding to HLA-DRB1*08:02 is shown in black, HLA-DRB1*11:01 in red, HLA-DRB1*11:04 in blue, HLA-DRB5*01:02 in green and HLA-DRB1*01:01 in magenta. The Top1 peptide is depicted by the backbone chain and CB atoms of the side chains as a stick and a ball, respectively. (B) Per-residue binding free energy of Top1 peptide for all five HLA-DRs.
