Figure 5
From: Interactions of HLA-DR and Topoisomerase I Epitope Modulated Genetic Risk for Systemic Sclerosis
Energetic fingerprints of difference (ΔΔGresidue) in per-residue free energy decomposition values of HLA-DR/Top1 complexes compared to non-associated with ATASSc HLA-DRB1*01:01. Energy contribution of HLA-DR residues for Top1 binding is illustrated by surface coloring. By comparing to per-residue decomposition energy of HLA-DRB1*01:01, the stronger binding is colored from yellow to red gradient and in contrast the weaker binding is shown in blue gradient.
