Table 2 Parameters, scores, distribution of specimens, medians and interquartile ranges of attributed scores according to histopathological analysis at 28 postoperative days after tooth extraction in VEH, VEH-PRP, ZOL and ZOL-PRP groups.
Histopathological Analysis | ||||
|---|---|---|---|---|
Parameters and Respective Scores | Number of Specimens | |||
Experimental Groups | ||||
VEH (n = 7) | VEH-PRP (n = 7) | ZOL (n = 7) | ZOL-PRP (n = 7) | |
Intensity of Local Inflammatory Response | ||||
(1) absence of inflammation | 7 | 7 | — | 4 |
(2) small quantity of inflammatory cells | — | — | — | 3 |
(3) moderate quantity of inflammatory cells | — | — | 3 | — |
(4) large quantity of inflammatory cells | — | — | 4 | — |
medians and interquatile ranges | 1 (1–1) | 1 (1–1) | 4†,‡ (3–4) | 1¶ (1–2) |
Inflammation Extension | ||||
(1) absence of inflammation | 7 | 7 | — | 4 |
(2) partial extension of connective tissue | — | — | — | 3 |
(3) entire extension of connective tissue, without reaching bone tissue | — | — | 2 | — |
(4) entire extension of connective tissue and bone tissue | — | — | 5 | — |
medians and interquatile ranges | 1 (1–1) | 1 (1–1) | 4†,‡ (3–4) | 1¶ (1–2) |
Cellular Pattern and Epithelial Tissue Structure | ||||
(1) moderate layer of epithelial tissue completely recovering extraction site | 4 | 5 | — | 3 |
(2) thin layer of epithelial tissue completely recovering extraction site | 3 | 2 | — | 4 |
(3) thin layer of epithelial tissue only in edges of open surgical wound | — | — | 4 | — |
(4) absence of epithelial tissue on open surgical wound | — | — | 3 | — |
medians and interquatile ranges | 1 (1–2) | 1 (1–2) | 3†,‡ (3–4) | 2¶ (1–2) |
Cellular Pattern and Connective Tissue Structure | ||||
(1) moderate quantity of fibroblasts and large quantity of collagen fibers | 4 | 5 | — | 3 |
(2) moderate quantity of both fibroblasts and collagen fibers | 3 | 2 | — | 4 |
(3) small quantity of both fibroblasts and collagen fibers | — | — | 2 | — |
(4) severe tissue disorganization with necrosis areas | — | — | 5 | — |
medians and interquatile ranges | 1 (1–2) | 1 (1–2) | 4†,‡ (3–4) | 2¶ (1–2) |
Cellular Pattern and Bone Tissue Structure | ||||
(1) absence of non-vital bone in tissues adjacent to the extraction site and trabecular bone filling more than half of extraction socket | 6 | 7 | — | 4 |
(2) absence of non-vital bone in tissues adjacent to the extraction site and trabecular bone filling less than half of extraction socket | 1 | — | — | 2 |
(3) presence of few areas with non-vital bone in tissues adjacent to the extraction site and trabecular bone filling less than a third of extraction socket | — | — | 2 | 1 |
(4) presence of many areas with non-vital bone in tissues adjacent to the extraction site and trabecular bone filling less than a third of extraction socket | — | — | 5 | — |
medians and interquatile ranges | 1 (1–2) | 1 (1–1) | 4†,‡ (3–4) | 1¶ (1–3) |
Contamination Pattern of Tooth Extraction Site | ||||
(1) presence of bacteria diffusely distributed in extraction site, typical of a normal condition | 7 | 7 | — | 4 |
(2) presence of large colonies of bacteria in soft tissues over extraction socket | — | — | — | 2 |
(3) presence of large colonies of bacteria in surface of alveolar bone and in the interior of the extraction socket | — | — | — | 1 |
(4) presence of large colonies of bacteria involving necrosed bone and/or in medullar spaces and in tissues adjacent to the extraction socket | — | — | 7 | — |
medians and interquatile ranges | 1 (1–1) | 1 (1–1) | 4†,‡ (4–4) | 1¶ (1–3) |
