Figure 2 | Scientific Reports

Figure 2

From: Dentate gyrus μ-opioid receptor-mediated neurogenic processes are associated with alterations in morphine self-administration

Figure 2

MSA increases MOR expression in the differentiated NSC progenies. (a) SGZ NSCs express MOR. (i) MOR screen of multiple cell markers. Scale bar represents 30 μm. (ii) Quantification of MOR/Marker colocalizations in the DG. (b) Schematic diagram outlining the experimental procedures of MSA and MOR quantification. (c) Rats develop a stable preference for the active (morphine-paired) hole. (i) Infusions of SSA and MSA. Treatment × Day: *p < 0.05; two-way repeated measures ANOVA. (ii) Inactive nosepokes of SSA and MSA. (d) MSA increases the number of DCX+ neurons with MOR coexpression. (i) Representative images in each group. Scale bar represents 30 μm. (ii) Quantification of MOR+/Marker+ percentage: **p < 0.01; unpaired student’s t test. All data are presented as mean ± s.e.m.

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