Figure 8 | Scientific Reports

Figure 8

From: RgsD negatively controls development, toxigenesis, stress response, and virulence in Aspergillus fumigatus

Figure 8

A model depicting the roles of RgsD. The putative RGS domain protein RgsD negatively regulates the cAMP-PKA signaling pathway, which may be activated by the Gα subunit GpaB. Consequence of the lack of RgsD leads to enhanced activation of the cAMP-PKA signaling pathway, which in turn leads to enhanced production of GT and melanin, and hyper-virulence of the fungus. The cAMP-PKA pathway may remove the repressive effects of VosA/VeA/NsdD on brlA and/or may directly activate brlA expression.

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