Figure 4
From: Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association
Surface complementarity of the SAMC monomer. (a) Ribbon and (b) surface representation of the NMR structure of the SAMC monomer are displayed in identical orientation. Surface colouring is based on electrostatic potential at pH 6.4 with negative charges in red and positive charges in blue. Helix α5 forms a hydrophobic ridge with negative charges on the left and hydrophobic residues on the right side. A positively charged ridge formed mainly by side chains of helices α1 and c2 exists. There is a hydrophobic groove between the two ridges. (c) Helix α5′ of the second monomer fits into this hydrophobic groove and side chains E311 and D315 of helix α5′ form salt bridges with residues that are part of the positively charged ridge.
