Figure 1
From: Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
Acute cold exposure increases circulating levels of FGF21. (A) Plasma FGF21 levels in 12 week old C57Bl/6J male mice cold exposed for the indicated amount of time (n = 7/group). (B-E) Fgf21 mRNA levels in (B) liver, (C) BAT, (D) iWAT and (E) eWAT from mice in (A). (F) Plasma FGF21 levels in 11–13 week old wild type (WT) and FGF21 LivKO male mice cold exposed for 1 hour (n = 5–6/group). Values are mean ± SEM; *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005; and #P ≤ 0.001 compared to time 0 for (A–E) and relative to WT for (F).
