Table 2 Univariate and multivariate analysis of prognostic factors for overall survival (OS) and progression free survival (PFS) in lung.
Characteristics | OS | PFS | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
Age, year | ||||||||
≤60 | 1 | 1 | 1 | 1 | ||||
>60 | 1.153 (0.608–2.186) | 0.662 | * | * | 1.243 (0.685–2.348) | 0.503 | * | * |
Gender | ||||||||
Female | 1 | 1 | 1 | 1 | ||||
Male | 1.258 (0.665–2.379) | 0.48 | * | * | 1.234 (0.652–2.332) | 0.518 | * | * |
Smoking history | ||||||||
No | 1 | 1 | 1 | |||||
Yes | 1.554 (0.821–2.939) | 0.176 | * | * | 1.523 (0.806–2.881) | 0.195 | * | * |
PKD2 expression | ||||||||
Low | 1 | 1 | 1 | 1 | ||||
High | 2.150 (1.136–4.071) | 0.019 | 1.344 (0.67–2.696) | 0.405 | 2.382 (1.257–4.516) | 0.008 | 1.577 (0.757–3.285) | 0.224 |
Pathological TMN stage | ||||||||
I | 1 | 1 | 1 | 1 | ||||
II | 2.369 (0.913–6.148) | 0.076 | 1.815 (0.685–4.807) | 0.231 | 2.436 (0.938–6.330) | 0.068 | 1.717 (0.629–4.684) | 0.194 |
III | 3.946 (1.799–8.655) | 0.001 | 2.554 (1.103–5.912) | 0.029 | 3.673 (1.674–8.058) | 0.001 | 2.325 (1.005–5.379) | 0.083 |
Differential degree | ||||||||
Well | 1 | 1 | 1 | 1 | ||||
Moderate | 9.492 (1.279–70.440) | 0.028 | 6.653 (0.876–50.522) | 0.067 | 9.776 (1.317–72.570) | 0.026 | 7.204 (0.948–54.768) | 0.056 |
Poor | 22.252 (2.929–169.029) | 0.003 | 13.904 (1.763–109.638) | 0.012 | 21.075 (2.776–160.005) | 0.003 | 13.685 (1.741–107.553) | 0.013 |
E-cadherin expression | ||||||||
Low | 1 | 1 | 1 | 1 | ||||
High | 0.357 (0.173–0.736) | 0.005 | 0.370 (0.174–0.786) | 0.010 | 0.355 (0.172–0.731) | 0.005 | 0.426 (0.199–0.914) | 0.028 |
