Figure 1

The multimodal image revealed compatible multiple polyps in manual-segmented OCTA and ICGA study and the BVN was clearer in OCTA. This was a 65 year-old female who was newly diagnosed as PCV by ICGA. (a) The fundus revealed nodular lesion and retinal hemorrhage. (b) The mid-phase ICGA revealed 3 polyps indicated by black arrows and BVN. (c) Transverse OCT B-scan image at the level corresponded to horizontal dash line in (a), revealed RPE detachment and sub-RPE iso-reflective lesion. (d) Vertical OCT B-scan image at the level corresponded to vertical dash line in (a), also revealed RPE detachment and sub-RPE iso-reflective lesion. (e) Automated OCTA en face image, which revealed BVN but no definite polyp. (f) OCTA en face image after manual adjustment of level of outer plexiform layer and bruch’s membrane, which clearly revealed 3 polyps (1~3) compatible with ICGA. (g) In the representative B-scan At the level of blue line in (e), the automatically set OPL (upper green line) and bruch’s membrane (lower green line) were deviated due to high PED. (h) In the representative B scan at the level of blue line in (f), the manually adjusted OPL (purple line) and bruch’s membrane (green line) produced en face image as in (f). (i,j). Polyp structure with high flow signal in angio-flowgram which lied around RPE (circle) and localization of polyp 3 (i) and polyp 1 (j).