Figure 3
From: In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma
13C NMR spectra acquired from glioma and contralateral normal-appearing brain (NAB) ex vivo after a steady-state [U-13C]leucine infusion. (a) Protocol for the [U-13C]leucine infusion. (b) Elevated leucine uptake and significantly higher (c) lactate and (d) glutamine labeling were observed in the tumor as compared to NAB, indicating an increased oxidation of leucine in the tumor. (e) 13C-labeled [4-13C]glutamate derived from [U-13C]leucine relative to the total glutamate pool size (%) from the leucine infusion study (*p < 0.05). D indicates doublet.
