Figure 4 | Scientific Reports

Figure 4

From: Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease

Figure 4

Interstitial fibrosis in white adipose tissue is reduced in BAFF−/− mice. (A) The median adipocyte size (left) and the distribution of adipocyte size (right) in EAT from HFD-fed BAFF−/− and WT mice. Representative (B) Sirius red staining and (C) quantification of Sirius red-positive areas of EAT (scale bar, 100 μm; images from 10 different fields; n = 6/group). (D) Total collagen contents in EAT (n = 9–13/group). (E) Expression of genes related to fibrosis in EAT (n = 14–15/group). For all bar plots, data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 (Mann-Whitney U test). BAFF, B cell-activating factor; HFD, high-fat diet; WT, wild-type; EAT, epididymal adipose tissue; TGF, transforming growth factor; SMA, smooth muscle actin; Col, Collagen.

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