Figure 2 | Scientific Reports

Figure 2

From: Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy

Figure 2

Histopathological analysis reveals drastic changes in EGFR and MIB1 status in re-recurrent GBM after EGFR inhibitor therapy. Microscopic pictures of H&E staining (top row) and IHC for EGFR (2nd row), phospho-EGFR (Tyr1068, 3rd row) and MIB-1 (Ki-67, the bottom row) for, from left to right column, original tumour MGG70 (70), recurrent tumour MGG70R (70R), re-recurrent tumour MGG70RR (70RR), and autopsy material MGG70A (70A). Original magnification, x200. Note negative staining of EGFR and phospho-EGFR in tumour-associated blood vessels (arrows). pEGFR positivity (% area) and MIB-1 labeling indices of each tumour are plotted on the right.

Back to article page