Table 2 Prognosis factors for poor visual outcome.

From: Prognostic Factors and Visual Outcomes of Pyogenic Liver Abscess-Related Endogenous Klebsiella pneumoniae Endophthalmitis: A 20-year retrospective review

Factors

 

Final visual outcome

Univariatea

Multivariateb

OR (95% CI)

P value

OR (95% CI)

P value

  

CF or better

Worse than CF

    

Patient characteristics

No. of eyes

No. of eyes (%)/ Mean ± SD

    

Age, yearsc

 

55.2 ± 10.9

56.9 ± 12.1

 

0.066

  

Length of hospital stay, daysc

 

24.2 ± 10.1

26.7 ± 11.8

 

0.283

  

Sexd

   Male

79

28(35.4%)

51(64.6%)

1

   

   Female

41

7(17.1%)

34(82.9%)

2.6(1.0–6.8)

0.060

  

Lateralitye

   Unilateral

88

21(23.9%)

67(76.1%)

2.8(1.2–6.6)

   

   Bilateral

32

15(46.9%)

17(53.1%)

1

0.017*

  

Diabetesd

Y = 82

23(28.0%)

59(72.0%)

1.2(0.5–2.7)

   
 

N = 38

12(31.6%)

26(68.4%)

1

0.693

  

Hypertensiond

Y = 46

11(23.9%)

35(76.1%)

1.5(0.7–3.5)

   
 

N = 74

24(32.4%)

50(67.6%)

1

0.314

  

Liver abscessesd

   Single

89

28(31.5%)

61(68.5%)

1

   

   Multiple

20

5(25.0%)

15(75.0%)

1.4(0.5–4.1)

0.564

  

Location of abscessese

   In right or left lobe

86

28(32.6%)

58(67.4%)

1

   

   In both lobes

10

1(10%)

9(90%)

4.3(0.5–36.0)

0.273

  

Maximal diameter of abscesses, cmc

 

5.3 ± 2.4

5.8 ± 2.5

1.1(0.9–1.3)

0.315

  

Presenting clinical features

Eye paind

Y = 79

18(22.8%)

61(77.2%)

2.8(1.2–6.3)

   
 

N = 40

18(45.0%)

22(55.0%)

1

0.013*

  

Fevere

Y = 104

32(30.8%)

72(69.2%)

1

   
 

N = 15

3(20%)

12(80%)

1.8(0.5–6.7)

0.548

  

Chillnessd

Y = 80

26(32.5%)

54(67.5%)

1

   
 

N = 38

9(23.7%)

29(76.3%)

1.6(0.6–3.7)

0.327

  

Abdominal paind

Y = 57

20(35.1%)

37(64.9%)

1

   
 

N = 62

15(21.2%)

47(75.8%)

1.7(0.8–3.7)

0.193

  

At presentation d

EE previous than PLA

62

8(12.9%)

54(87.1%)

6.1(2.5–15.0)

   

PLA previous than EE

57

27(47.4%)

30(52.6%)

1

<0.001*

5.1(1.6–16.6)

0.007*

Times of ocular symptoms to ophthalmologist consult, daysc

 

2.1 ± 1.5

2.9 ± 1.8

1.4(1.1–1.9)

0.022*

  

Ocular and laboratory examination

Initial VA worse than CFd

Y = 76

10(13.2%)

66(86.8%)

8.7(3.6–21.2)

   
 

N = 44

25(56.8%)

19(43.2%)

1

<0.001*

4.6(1.6–13.4)

0.004*

Ocular hypertensiond

Y = 46

4(8.7%)

42(91.3%)

7.6(2.5–23.3)

   
 

N = 74

31(41.9%)

43(58.1%)

1

<0.001*

  

IOP, mmHgc

 

16.5 ± 9.9

26.3 ± 11.7

1.1(1.0–1.2)

0.003*

  

Corneal edemad

Y = 82

16(20%)

66(80%)

6.4(2.3–18.0)

   
 

N = 36

19(52.8%)

17(47.2%)

1

<0.001*

  

Hypopyond

Y = 49

7(14.3%)

42(85.7%)

3.9(1.5–9.9)

   
 

N = 71

28(39.4%)

43(60.6%)

1

0.003*

  

Subretinal abscesse

Y = 113

30(26.5%)

83(73.5%)

6.9(1.3–37.6)

0.025*

  
 

N = 7

5(71.4%)

2(28.6%)

1

   

WBC count (x 109/L)c

 

17.3 ± 14.5

14.2 ± 6.5

 

0.244

  

Thrombocytopeniad

Y = 63

26(41.3%)

37(58.7%)

1

   

(<100,000/mm3)

N = 49

8(16.3%)

41(83.7%)

3.6(1.5–8.9)

0.006*

  

ASTc

 

118.9 ± 127.8

58.4 ± 51.6

 

0.076

  

ALTc

 

109.7 ± 111.2

78.3 ± 68.0

 

0.183

  

Alk-Pc

 

195.7 ± 115.5

209.8 ± 112.4

 

0.671

  

HbA1c in DM patientsc

 

10.0 ± 3.2

8.8 ± 3.0

 

0.245

  

Blood cultured

Y = 84

25(29.8%)

59(70.2%)

1

   
 

N = 36

10(27.8%)

26(72.2%)

1.1(0.5–2.6)

0.826

  

Aqueous or vitreous cultured

Y = 40

2(5.0%)

38(95.0%)

13.3(3.0–59.2)

   
 

N = 80

33(41.2%)

47(58.8%)

1

<0.001*

4.9(0.9–26.4)

0.059

Treatment

Abscess drainaged

Y = 68

24(35.3%)

44(64.7%)

1

   
 

N = 52

11(21.2%)

41(78.8%)

2.0(0.9–4.7)

0.091

  

IVI of antibioticsd

   With dexamethasone

34

14(41.2%)

20(58.8%)

1

   

   Without dexamethasone

86

21(24.4%)

65(75.6%)

2.2(0.9–5.0)

0.069

  

Early TPPVd

Y = 26

5(19.2%)

21(80.8%)

2.0(0.7–5.7)

   
 

N = 94

30(31.9%)

64(68.1%)

1

0.208

  
  1. Note; CF, counting fingers; CI, confidence interval; IOP, intraocular pressure; IVI, intravitreal injection; TPPV, trans pars plana vitrectomy; VA, visual acuity; WBC, white blood cell; EE, endogenous endophthalmitis; PLA, pyogenic liver abscess; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Alk-P, alkaline phosphatase; *statistical significant aunivariate logistic regression; bBinary logistic regression; cStudent’s t test; dPearson’s chi square test; Fisher’s Exact test.