Table 2 Genes modulated in T CD4 cells: infected vs uninfected (DMSO_I vs DMSO), uninfected treated with ABX464 vs uninfected and untreated (464 vs DMSO) and infected treated with ABX464 vs infected and untreated (464_I vs DMSO_I).

From: Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing

Gene Symbol

Ensembl ID

chr

description

log2(FC)

FC

P-Value

SNORD104

ENSG00000199753

17

small nucleolar RNA, C/D box 104

−1,593239134

0,3314265

0,000113748

MZT2B

ENSG00000152082

2

mitotic spindle organizing protein 2B

−1,545615646

0,342549493

0,005014214

HLA-L

ENSG00000243753

6

major histocompatibility complex, class I, L (pseudogene)

−2,155554923

0,224446745

0,018996735

FMO5

ENSG00000131781

1

flavin containing monooxygenase 5

−2,32723033

0,199266303

0,022279359

RP11-69M1.6

ENSG00000279865

12

pseudogene

−1,75254756

0,296777256

0,040623948

UBE4A

ENSG00000110344

11

ubiquitination factor E4A

−2,226441782

0,2136851

0,039977521

SNORD3A

ENSG00000263934

17

small nucleolar RNA, C/D box 3A

−2,648926643

0,159438656

0,041651979

HIST1H1E

ENSG00000168298

6

histone cluster 1 H1 family member

−2,769812645

0,146623409

0,043246739

PKD2

ENSG00000118762

4

polycystin 2, transient receptor potential cation channel

−3,020380563

0,123246573

0,014543367

NAALADL1

ENSG00000168060

11

N-acetylated alpha-linked acidic dipeptidase like 1

−3,333148179

0,099225299

0,012581

RNU4-1

ENSG00000200795

12

RNA, U4 small nuclear 1

−3,972391545

0,063707563

0,014002979

RNU4-2

ENSG00000202538

12

RNA, U4 small nuclear 2

−3,830896068

0,070272495

0,010356151

MOSPD3

ENSG00000106330

7

motile sperm domain containing 3

−3,845633809

0,069558286

0,022670456

FP236383.10

ENSG00000277105

8

miRNA

−3,494083339

0,088751583

0,040882842

NBPF20

ENSG00000162825

1

Neuroblastoma Breakpoint Family, Member 20

−4,017571383

0,061743395

0,001624932

ABX464_NI_vs DMSO_NI

SNORD3A

ENSG00000263934

17

small nucleolar RNA, C/D box 3A

−2,923985868

0,13176

0,026481173

HELLS

ENSG00000119969

10

helicase, lymphoid specific

−2,246421514

0,21075

0,018558217

MZT2B

ENSG00000152082

2

mitotic spindle organizing protein 2B

−1,658291634

0,31681

0,002657817

HIST1H1D

ENSG00000124575

6

histone cluster 1 H1 family member d

−1,559586171

0,33925

5,18E-05

RPS19BP1

ENSG00000187051

22

ribosomal protein S19 binding protein 1

−1,566230636

0,33769

0,000115799

NDUFB7

ENSG00000099795

19

NADH:ubiquinone oxidoreductase subunit B7

−1,520475764

0,34857

0,000168054

CECR1

ENSG00000093072

22

Adenosine Deaminase 2

1,842665068

3,58672

2,65E-18

DPF2

ENSG00000133884

11

double PHD fingers 2

1,560531204

2,94962

2,45E-11

HOPX

ENSG00000171476

4

HOP Homeobox

1,744005457

3,34964

1,47E-07

LARS2

ENSG00000011376

3

leucyl-tRNA synthetase 2, mitochondrial

1,580307045

2,99033

0,026767164

TOR1AIP2

ENSG00000169905

1

torsin 1A interacting protein 2

3,485915121

11,20379

2,59E-16

SCML1

ENSG00000047634

X

Scm polycomb group protein like 1

3,229297195

9,37811

9,67E-11

PPP1R2

ENSG00000184203

3

protein phosphatase 1 regulatory inhibitor subunit 2

3,136231549

8,79224

2,52E-05

ABX464_I_vs_DMSO_I

CECR1

ENSG00000093072

22

Adenosine Deaminase 2

1,770654479

3,41208711

4,33E-17

DPF2

ENSG00000133884

11

double PHD fingers 2

1,61885639

3,071314797

4,52E-12

NOP9

ENSG00000196943

14

NOP9 nucleolar protein

1,594464835

3,019824765

4,35E-06

LGALS3

ENSG00000131981

14

galectin 3

1,589357824

3,009153755

0,723536038

LARS2

ENSG00000011376

3

leucyl-tRNA synthetase 2, mitochondrial

1,580389838

2,990506469

0,025849185

SCML1

ENSG00000047634

X

Scm polycomb group protein like 1

2,85086263

7,214316067

3,52E-09

NBPF20

ENSG00000162825

1

Neuroblastoma Breakpoint Family, Member 20

3,029199621

8,163566761

0,013076519

TOR1AIP2

ENSG00000169905

1

torsin 1A interacting protein 2

3,84681594

14,38821722

6,11E-19

PPP1R2

ENSG00000184203

3

protein phosphatase 1 regulatory inhibitor subunit 2

4,073227898

16,83308732

1,35E-07