Table 2 Genes modulated in T CD4 cells: infected vs uninfected (DMSO_I vs DMSO), uninfected treated with ABX464 vs uninfected and untreated (464 vs DMSO) and infected treated with ABX464 vs infected and untreated (464_I vs DMSO_I).
Gene Symbol | Ensembl ID | chr | description | log2(FC) | FC | P-Value |
---|---|---|---|---|---|---|
SNORD104 | ENSG00000199753 | 17 | small nucleolar RNA, C/D box 104 | −1,593239134 | 0,3314265 | 0,000113748 |
MZT2B | ENSG00000152082 | 2 | mitotic spindle organizing protein 2B | −1,545615646 | 0,342549493 | 0,005014214 |
HLA-L | ENSG00000243753 | 6 | major histocompatibility complex, class I, L (pseudogene) | −2,155554923 | 0,224446745 | 0,018996735 |
FMO5 | ENSG00000131781 | 1 | flavin containing monooxygenase 5 | −2,32723033 | 0,199266303 | 0,022279359 |
RP11-69M1.6 | ENSG00000279865 | 12 | pseudogene | −1,75254756 | 0,296777256 | 0,040623948 |
UBE4A | ENSG00000110344 | 11 | ubiquitination factor E4A | −2,226441782 | 0,2136851 | 0,039977521 |
SNORD3A | ENSG00000263934 | 17 | small nucleolar RNA, C/D box 3A | −2,648926643 | 0,159438656 | 0,041651979 |
HIST1H1E | ENSG00000168298 | 6 | histone cluster 1 H1 family member | −2,769812645 | 0,146623409 | 0,043246739 |
PKD2 | ENSG00000118762 | 4 | polycystin 2, transient receptor potential cation channel | −3,020380563 | 0,123246573 | 0,014543367 |
NAALADL1 | ENSG00000168060 | 11 | N-acetylated alpha-linked acidic dipeptidase like 1 | −3,333148179 | 0,099225299 | 0,012581 |
RNU4-1 | ENSG00000200795 | 12 | RNA, U4 small nuclear 1 | −3,972391545 | 0,063707563 | 0,014002979 |
RNU4-2 | ENSG00000202538 | 12 | RNA, U4 small nuclear 2 | −3,830896068 | 0,070272495 | 0,010356151 |
MOSPD3 | ENSG00000106330 | 7 | motile sperm domain containing 3 | −3,845633809 | 0,069558286 | 0,022670456 |
FP236383.10 | ENSG00000277105 | 8 | miRNA | −3,494083339 | 0,088751583 | 0,040882842 |
NBPF20 | ENSG00000162825 | 1 | Neuroblastoma Breakpoint Family, Member 20 | −4,017571383 | 0,061743395 | 0,001624932 |
ABX464_NI_vs DMSO_NI | ||||||
SNORD3A | ENSG00000263934 | 17 | small nucleolar RNA, C/D box 3A | −2,923985868 | 0,13176 | 0,026481173 |
HELLS | ENSG00000119969 | 10 | helicase, lymphoid specific | −2,246421514 | 0,21075 | 0,018558217 |
MZT2B | ENSG00000152082 | 2 | mitotic spindle organizing protein 2B | −1,658291634 | 0,31681 | 0,002657817 |
HIST1H1D | ENSG00000124575 | 6 | histone cluster 1 H1 family member d | −1,559586171 | 0,33925 | 5,18E-05 |
RPS19BP1 | ENSG00000187051 | 22 | ribosomal protein S19 binding protein 1 | −1,566230636 | 0,33769 | 0,000115799 |
NDUFB7 | ENSG00000099795 | 19 | NADH:ubiquinone oxidoreductase subunit B7 | −1,520475764 | 0,34857 | 0,000168054 |
CECR1 | ENSG00000093072 | 22 | Adenosine Deaminase 2 | 1,842665068 | 3,58672 | 2,65E-18 |
DPF2 | ENSG00000133884 | 11 | double PHD fingers 2 | 1,560531204 | 2,94962 | 2,45E-11 |
HOPX | ENSG00000171476 | 4 | HOP Homeobox | 1,744005457 | 3,34964 | 1,47E-07 |
LARS2 | ENSG00000011376 | 3 | leucyl-tRNA synthetase 2, mitochondrial | 1,580307045 | 2,99033 | 0,026767164 |
TOR1AIP2 | ENSG00000169905 | 1 | torsin 1A interacting protein 2 | 3,485915121 | 11,20379 | 2,59E-16 |
SCML1 | ENSG00000047634 | X | Scm polycomb group protein like 1 | 3,229297195 | 9,37811 | 9,67E-11 |
PPP1R2 | ENSG00000184203 | 3 | protein phosphatase 1 regulatory inhibitor subunit 2 | 3,136231549 | 8,79224 | 2,52E-05 |
ABX464_I_vs_DMSO_I | ||||||
CECR1 | ENSG00000093072 | 22 | Adenosine Deaminase 2 | 1,770654479 | 3,41208711 | 4,33E-17 |
DPF2 | ENSG00000133884 | 11 | double PHD fingers 2 | 1,61885639 | 3,071314797 | 4,52E-12 |
NOP9 | ENSG00000196943 | 14 | NOP9 nucleolar protein | 1,594464835 | 3,019824765 | 4,35E-06 |
LGALS3 | ENSG00000131981 | 14 | galectin 3 | 1,589357824 | 3,009153755 | 0,723536038 |
LARS2 | ENSG00000011376 | 3 | leucyl-tRNA synthetase 2, mitochondrial | 1,580389838 | 2,990506469 | 0,025849185 |
SCML1 | ENSG00000047634 | X | Scm polycomb group protein like 1 | 2,85086263 | 7,214316067 | 3,52E-09 |
NBPF20 | ENSG00000162825 | 1 | Neuroblastoma Breakpoint Family, Member 20 | 3,029199621 | 8,163566761 | 0,013076519 |
TOR1AIP2 | ENSG00000169905 | 1 | torsin 1A interacting protein 2 | 3,84681594 | 14,38821722 | 6,11E-19 |
PPP1R2 | ENSG00000184203 | 3 | protein phosphatase 1 regulatory inhibitor subunit 2 | 4,073227898 | 16,83308732 | 1,35E-07 |