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Figure 1

From: Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

Figure 1

Cardiac function and survival in acute Dox cardiomyopathy mice. (A) Schematic of acute Dox administration protocol. FVB/N mice of 8 to 10-weeks of age were treated with a single dose of Dox (20 mg/kg) and vehicle by i.p. injections. (B) Kaplan Meier survival curve showing significant mortality in mice after acute Dox (n = 22) treatment compared to Vehicle (n = 10) treated mice. M mode echocardiography was used to examine cardiac function before as well as 3 and 5 days after Dox- and vehicle-injection. (C) LV systolic internal dimension (LVID; s). (D) LV diastolic internal dimension (LVID; d). (E) Percentage fractional shortening (%FS). (F) LV systolic volume (LV Vol; s). (G) LV diastolic volume (LV Vol; d). (H) Percentage ejection fraction (%EF). (I) LV diastolic posterior wall thickness (LVPW; d). (J) LV diastolic interventricular septum thickness (IVS; d). (K) LV mass. Data represent mean ± SEM. n = 9 mice for Dox-treatment group and n = 5 mice for vehicle treatment group. P value versus vehicle-treated mice by Tukey’s post hoc test. NS, not significant.

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