Figure 6 | Scientific Reports

Figure 6

From: Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration

Figure 6

Cardiac function and survival in chronic Dox-associated cardiomyopathy mice. (A) Schematic of chronic Dox administration protocol. FVB/N mice of 8 to 10-weeks of age were subjected to four serial Dox (5 mg/kg) injections weekly by i.p. (B) Kaplan Meier survival curve showing mortality in mice after chronic Dox (n = 13) treatment compared to Vehicle (n = 10) treated mice. M mode echocardiography was used to examine cardiac functions before as well as 4, 8 and 12 weeks after Dox and vehicle-injection. (C) LV systolic internal dimension (LVID; s). (D) LV diastolic internal dimension (LVID; d). (E) Percentage fractional shortening (%FS). (F) LV systolic volume (LV Vol; s). (G) LV diastolic volume (LV Vol; d). (H) Percentage ejection fraction (%EF). (I) LV diastolic posterior wall thickness (LVPW; d). (J) LV diastolic interventricular septum thickness (IVS; d). (K) LV mass. n = 15 mice for Dox-treatment group and n = 5 mice for vehicle treatment group. Bars represent mean ± SEM. P value versus vehicle-treated mice by Tukey’s post hoc test. NS, not significant.

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