Table 1 Number of treated patients and association of chemotherapeutic and immunosuppressive agents with secondary BAT activity.
Overall (n) | BAT activity (n) | p-value | Effect on BAT | |
|---|---|---|---|---|
Alkylating agents | ||||
Cyclophosphamide | 62 | 8 | 0.11 | |
Ifosfamide | 28 | 2 | 1.00 | |
Dacarbazine | 11 | 1 | 1.00 | |
Procarbazine | 11 | 2 | 1.00 | |
Melphalan | 9 | 1 | 1.00 | |
Carmustine | 5 | 1 | 1.00 | |
Temozolomide | 3 | 1 | 1.00 | |
Thiotepum | 2 | 0 | 1.00 | |
Bendamustine | 2 | 0 | 1.00 | |
Platinum-based agents | ||||
Cisplatin | 79 | 3 | 1.00 | |
Carboplatin | 21 | 1 | 1.00 | |
Oxaliplatin | 16 | 1 | 1.00 | |
Anthracyclines | ||||
Doxorubicin | 47 | 8 | 0.006* | activation |
Epirubicin | 9 | 0 | 1.00 | |
Daunorubicin | 2 | 1 | 0.92 | |
Idarubicin | 1 | 0 | 1.00 | |
Mitoxantrone | 1 | 0 | 1.00 | |
Peptid antibiotics | ||||
Bleomycin | 15 | 2 | 1.00 | |
Mitomycin C | 13 | 2 | 1.00 | |
Actinomycin D | 1 | 0 | 1.00 | |
Vinca alkaloids | ||||
Vincristine | 50 | 9 | 0.002* | activation |
Vinorelbine | 14 | 0 | 1.00 | |
Vindesine | 7 | 3 | 0.045* | activation |
Vinblastine | 6 | 1 | 1.00 | |
Taxanes | ||||
Paclitaxel | 29 | 1 | 1.00 | |
Docetaxel | 5 | 0 | 1.00 | |
Inhibitors of Topoisomerases | ||||
Etoposide | 53 | 7 | 0.15 | |
Irinotecan | 3 | 0 | 1.00 | |
Topotecan | 1 | 0 | 1.00 | |
Nucleotied analogs and precursor analogs | ||||
Fluoruracil | 37 | 0 | 0.93 | |
Cytarabine | 20 | 7 | <0.0008* | activation |
Methotrexate | 18 | 3 | 0.67 | |
Azathioprine | 6 | 0 | 1.00 | |
Fludarabine | 5 | 0 | 1.00 | |
Gemcitabine | 5 | 0 | 1.00 | |
Capecitabine | 4 | 1 | 1.00 | |
Tioguanine | 1 | 1 | 0.47 | |
Mercaptopurine | 1 | 1 | 0.47 | |
Cladribine | 1 | 0 | 1.00 | |
Clofarabine | 1 | 1 | 0.47 | |
Other | ||||
Steroids | 64 | 12 | <0.0008* | activation |
Rituximab | 42 | 4 | 1.00 | |
Other mAb | 13 | 0 | 1.00 | |
Imatinib | 13 | 0 | 1.00 | |
Motesanib | 8 | 0 | 1.00 | |
Mycophenolate Mofetil | 6 | 1 | 1.00 | |
Cyclosporin A | 2 | 0 | 1.00 | |
Leflunomide | 2 | 0 | 1.00 | |
Tacrolimus | 2 | 0 | 1.00 | |
Everolimus | 2 | 0 | 1.00 | |
Tamoxifen | 2 | 0 | 1.00 | |
Anastrozole | 1 | 0 | 1.00 | |
Sirolimus | 1 | 1 | 0.47 | |
